双特异性磷酸酶抗体12抗体
规格：1mg/1ml
英文名： DUSP12
别名： Dual specificity phosphatase 11; Dual specificity protein phosphatase 11; DUS11_HUMAN; DUSP11; Phosphatase that interacts with RNA/RNP complex 1; PIR1; RNA/RNP complex 1 interacting; RNA/RNP complex i
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DUSP12
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：
双特异性磷酸酶抗体12抗体产品介绍：background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility 双特异性磷酸酶抗体12抗体of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008] Function: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism. Subcellular Location: Nucleus. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 双特异性磷酸酶抗体12抗体Contains 1 tyrosine-protein phosphatase domain. Gene ID: 8446 Database links: Entrez Gene: 8446 Human Entrez Gene: 72102 Mouse Entrez Gene: 297412 Rat Omim: 603092 Human SwissProt: O75319 Human SwissProt: Q6NXK5 Mouse SwissProt: Q4KM79 Rat Unigene: 14611 Human Unigene: 24007 Mouse Unigene: 24649 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
双特异性磷酸酶抗体12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid