DRAM2蛋白抗体
规格：1mg/1ml
英文名： DRAM2
别名： 2010305N14Rik; 2610318G18Rik; AI647667; damage regulated autophagy modulator 2; DNA damage regulated autophagy modulator 2; DNA damage regulated autophagy modulator protein 2; DNA damage-regulated aut
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DRAM2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
DRAM2蛋白抗体产品介绍：background: TMEM77 (transmembrane protein 77) is a 266 amino acid protein encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible forDRAM2蛋白抗体 familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. Function: Induces apoptotic cell deathDRAM2蛋白抗体 when co-expressed with DRAM1. Subcellular Location: Lysosome membrane. Tissue Specificity: Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Not detected in brain or thymus. Similarity: Belongs to the DRAM/TMEM150 family. Gene ID: 128338 Database links: Entrez Gene: 128338 Human Omim: 613360 Human SwissProt: Q6UX65 Human Unigene: 485606 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DRAM2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid