DOCK8蛋白抗体
规格：1mg/1ml
英文名： DOCK8
别名： 1200017A24Rik; Dedicator of cytokinesis protein 8; DOCK8; DOCK8_HUMAN; MRD2; ZIR8.
分子量： 239kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DOCK8
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：
DOCK8蛋白抗体产品介绍：background: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010] Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins DOCK8蛋白抗体activate some small GTPases by exchanging bound GDP for free GTP. DISEASE: Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES) [MIM:243700]. It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. SimilarityDOCK8蛋白抗体: Belongs to the DOCK family. Contains 1 DHR-1 (CZH-1) domain. Contains 1 DHR-2 (CZH-2) domain. Gene ID: 81704 Database links: Entrez Gene: 81704 Human Omim: 611432 Human SwissProt: Q8NF50 Human Unigene: 132599 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DOCK8蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid