DNAJC5B蛋白抗体
规格：1mg/1ml
英文名： DNAJC5B
别名： Beta CSP; Beta cysteine string protein; CSP beta; DNJ5B_HUMAN; DnaJ (Hsp40) homolog, subfamily C, member 5 beta; DnaJ homolog subfamily C member 5B; MGC26226.
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DNAJC5B
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
DNAJC5B蛋白抗体产品介绍：background: The DnaJ family, one of the largest of all the chaperone families, has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat-shock induced proteins are derived from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. Members of this family contain cysteine-rich regions that are composed of zinc fingers that form a peptide-binding domain responsible for the chaperone function. They are important mediators of proteolysis andDNAJC5B蛋白抗体 are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJC5B is a 199 amino acid protein that contains one J domain and plays an important role in exocytosis. DnaJC5B is expressed in testis where it is tightly bound to lipid membranes. The palmitoylation level of DnaJC5B is thought to correlate with its targeting to specific membranes. Function: DnaJ is a testis-specific heat shock protein and functions in association with DnaK(Hsp70). It is a molecular chaperone to facilitate protein folding. DnaJ plays a key role in the chaperone reaction by DNAJC5B蛋白抗体stimulating the ATPase activity and activating the substrate binding of Hsp70. Subcellular Location: Membrane; Lipid-anchor. Tissue Specificity: Testis specific. Post-translational modifications: Palmitoylated. Palmitoylation is not required for membrane association. Similarity: Contains 1 J domain. Gene ID: 85479 Database links: Entrez Gene: 85479 Human Entrez Gene: 66326 Mouse GenBank: NM_033105 Human SwissProt: Q9UF47 Human SwissProt: Q9CQ94 Mouse Unigene: 491885 Human Unigene: 45615 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DNAJC5B蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid