DENND1C蛋白抗体
规格：1mg/1ml
英文名： DENND1C
别名： Connecdenn 3; DEN1C_HUMAN; DENN domain-containing protein 1C; Dennd1c; FAM31C; FLJ22757; Protein FAM31C.
分子量： 87kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DENND1C
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞浆
DENND1C蛋白抗体产品介绍：background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010] FunctionDENND1C蛋白抗体: Guanine nucleotide exchange factor (GEF) for RAB35 Subunit: Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1. Subcellular Location: Cytoplasm; cytosol. Cytoplasmic vesicle;DENND1C蛋白抗体 clathrin-coated vesicle. Similarity: Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 uDENN domain Gene ID: 79958 Database links: Entrez Gene: 79958 Human Omim: 613634 Human SwissProt: Q8IV53 Human Unigene: 236449 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DENND1C蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞骨架 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid