芳香烃受体抗体
规格：1mg/1ml
英文名： AHR
别名： Ah receptor; AHR; Aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; BHLHE76; Class E basic helix loop helix protein 76; HGNC:348; AHR_HUMAN.
分子量： 93kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Aryl Hyd
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
芳香烃受体抗体产品介绍：background: This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important 芳香烃受体抗体role in the development and maturation of many tissues. Subcellular Location: Cytoplasm. Nucleus. Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. Tissue Specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. Gene ID: 196 Database links: Entrez Gene: 196 Human Entrez Gene: 11622 Mouse Entrez芳香烃受体抗体 Gene: 25690 Rat Omim: 600253 Human SwissProt: P35869 Human SwissProt: P30561 Mouse SwissProt: P41738 Rat Unigene: 171189 Human Unigene: 341377 Mouse Unigene: 91370 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子芳香烃受体抗体（Transcriptin Regulators） 芳香烃受体（AHR）是一种配体激活转录因子,可介导多环芳烃类化合物的毒性（包括致癌性）反应,还参与一些重要的生物学过程,如信号转导、细胞分化、细胞凋亡等。人体的肺、肝、肾、胎盘、腭扁桃体、B**细胞等各种组织和细胞中都存在AHR。AHR对生长发育和生理功能等具有调控作用,在一些癌症（乳腺癌和卵巢癌等）发**展中起促进作用。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid