细胞分裂相关蛋白CSTF64T抗体
规格：1mg/1ml
英文名： CSTF2T
别名： CF 1 64 kDa subunit tau; CF-1 64 kDa subunit tau variant; CF1 64 kDa subunit, tau variant; Cleavage stimulation factor 3' pre RNA, subunit 2 64kDa tau variant; Cleavage stimulation factor 64 kDa subun
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CSTF2T
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit,
细胞定位：细胞核
细胞分裂相关蛋白CSTF64T抗体产品介绍：background: Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ 细胞分裂相关蛋白CSTF64T抗体cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation. Function: May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs.细胞分裂相关蛋白CSTF64T抗体 Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 RRM (RNA recognition motif) domain. Gene ID: 23283 Database links: Entrez Gene: 23283 Human Entrez Gene: 83410 Mouse Entrez Gene: 309338 Rat Omim: 611968 Human SwissProt: Q9H0L4 Human SwissProt: Q8C7E9 Mouse Unigene: 591358 Human Unigene: 482352 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞分裂相关蛋白CSTF64T抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid