转录激活蛋白CRSP8抗体
规格：1mg/1ml
英文名： CRSP8
别名： Cofactor required for Sp1 transcriptional activation subunit 8 (34kD); Cofactor required for Sp1 transcriptional activation subunit 8 34kDa; Cofactor required for Sp1 transcriptional activation subuni
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CRSP8
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞核
转录激活蛋白CRSP8抗体产品介绍：background: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.转录激活蛋白CRSP8抗体 Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011] Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions 转录激活蛋白CRSP8抗体with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Subcellular Location: Nucleus. Similarity: Belongs to the Mediator complex subunit 27 family. Gene ID: 9442 Database links: Entrez Gene: 9442 Human Entrez Gene: 525389 Cow Entrez Gene: 68975 Mouse Entrez Gene: 414430 Pig Entrez Gene: 296612 Rat Omim: 605044 Human SwissProt: Q2TBN7 Cow SwissProt: Q6P2C8 Human SwissProt: Q9DB40 Mouse SwissProt: Q6Q7J5 Pig Unigene: 374262 Human Unigene: 330109 Mouse Unigene: 105472 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录激活蛋白CRSP8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid