环腺苷酸应答元件结合蛋白样蛋白2抗体
规格：1mg/1ml
英文名： CREBL2
别名： cAMP responsive element binding protein like 2; CREBL 2; MGC117311; MGC138362; MHBs-binding protein 1; CRBL2_HUMAN.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CREBL2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,
细胞定位：细胞核
环腺苷酸应答元件结合蛋白样蛋白2抗体产品介绍：background: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. 环腺苷酸应答元件结合蛋白样蛋白2抗体[provided by RefSeq, Jul 2008] Function: CREBL2 is frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. Subunit: Interacts with CREB1; regulates CREB1 环腺苷酸应答元件结合蛋白样蛋白2抗体phosphorylation, stability and transcriptional activity (By similarity). Subcellular Location: Nuclear Post-translational modifications: Phosphorylated by AMPK. Similarity: Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP (basic-leucine zipper) domain. Gene ID: 1389 Database links: Entrez Gene: 1389 Human Entrez Gene: 537195 Cow Entrez Gene: 232430 Mouse Entrez Gene: 362453 Rat Entrez Gene: 100038265 Xenopus tropicalis Omim: 603476 Human SwissProt: Q0VD32 Cow SwissProt: O60519 Human SwissProt: Q32M00 Mouse SwissProt: Q5BJU6 Rat SwissProt: A4IGK3 Xenopus tropicalis Unigene: 591156 Human Unigene: 267010 Mouse Unigene: 107553 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环腺苷酸应答元件结合蛋白样蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 染色质和核信号 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid