环腺苷酸应答元件结合蛋白3样蛋白1抗体
规格：1mg/1ml
英文名： CREB3L1
别名： BBF-2 homolog; CAMP responsive element binding protein 3 like 1; cAMP-responsive element-binding protein 3-like protein 1; CR3L1_HUMAN; Creb3l1; Cyclic AMP responsive element binding protein 3 like pr
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CREB3L1
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse,
细胞定位：细胞核
环腺苷酸应答元件结合蛋白3样蛋白1抗体产品介绍：background: The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013] Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. 环腺苷酸应答元件结合蛋白3样蛋白1抗体Subcellular Location: Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. Tissue Specificity: Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain. Post-translational modifications: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1环腺苷酸应答元件结合蛋白3样蛋白1抗体 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus. Similarity: Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP domain. Gene ID: 90993 Database links: Entrez Gene: 90993 Human Entrez Gene: 26427 Mouse Entrez Gene: 362165 Rat SwissProt: Q96BA8 Human SwissProt: Q9Z125 Mouse SwissProt: Q66HA2 Rat Unigene: 405961 Human Unigene: 10353 Mouse Unigene: 24541 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环腺苷酸应答元件结合蛋白3样蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid