线粒体肌酸激酶CKMT抗体
规格：1mg/1ml
英文名： Creatine kinase MT
别名： Acidic type mitochondrial creatine kinase; CKMT; CKMT1; CKMT1A; CKMT1B; Creatine kinase mitochondrial 1 ubiquitous; Creatine kinase ubiquitous mitochondrial; Mia CK; Ubiquitous mitochondrial creatine
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Creatine
交叉反应：Human, Mouse, Rat, Chicken, Pig, Sheep,
细胞定位：细胞膜
线粒体肌酸激酶CKMT抗体产品介绍：background: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. 线粒体肌酸激酶CKMT抗体Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008] Function: Creatine kinase MT is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Creatine kinase MT occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80%线粒体肌酸激酶CKMT抗体 homology with the coding exons of sarcomeric mitochondrial creatine kinase. Subcellular Location: Cell Membrane and Mitochondrial Similarity: Belongs to the ATP:guanido phosphotransferase family. Contains 1 phosphagen kinase C-terminal domain. Contains 1 phosphagen kinase N-terminal domain. Gene ID: 1159 Database links: Entrez Gene: 1159 Human Entrez Gene: 281692 Cow Entrez Gene: 548596 Human Entrez Gene: 12716 Mouse Entrez Gene: 29593 Rat Entrez Gene: 321892 Zebrafish Omim: 123290 Human SwissProt: Q9TTK8 Cow SwissProt: P12532 Human SwissProt: P30275 Mouse SwissProt: Q29577 Pig SwissProt: P25809 Rat SwissProt: Q7ZUN7 Zebrafish Unigene: 425633 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
线粒体肌酸激酶CKMT抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞凋亡 激酶和磷酸酶 细胞骨架 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid