CRB2蛋白抗体
规格：1mg/1ml
英文名： CRB2
别名： Crb2; CRUM2_HUMAN; Crumbs homolog 2 (Drosophila); Crumbs homolog 2; Crumbs-like protein 2; RP11-230L22.2.
分子量： 100, 123, 131kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CRB2
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
CRB2蛋白抗体产品介绍：background: CRB2 is a 1,285 amino acid protein that contains three laminin G-like domains and 15 EGF-like domains and exists as multiple alternatively spliced isoforms that are either secreted or membrane bound. Expressed in kidney and retina, as well as in fetal eye and brain, CRB2 is thought to play a role in the morphogenesis of polarized cells and may be involved in DNA repair. Defects in the gene encoding CRB2 are associated with the pathogenesis of autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), the former of which refers to a group of diseases that lead to the degeneration of retinal photoreceptor cells, ultimately resulting in a lossCRB2蛋白抗体 of vision. The gene encoding CRB2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Function: May play a role in polarized cells morphogenesis. Subcellular Location: Secreted and Cell membrane. Tissue Specificity: Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, CRB2蛋白抗体and heart. Similarity: Belongs to the Crumbs protein family. Contains 15 EGF-like domains. Contains 3 laminin G-like domains. Gene ID: 286204 Database links: Entrez Gene: 286204 Human Entrez Gene: 241324 Mouse Entrez Gene: 366031 Rat Omim: 609720 Human SwissProt: Q5IJ48 Human SwissProt: Q80YA8 Mouse Unigene: 710092 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CRB2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid