剪切及多聚腺苷酸化特异性因子6蛋白抗体
规格：1mg/1ml
英文名： CPSF6
别名： CFIm68; Cleavage and polyadenylation specificity factor 68 kDa subunit; Cleavage and polyadenylation specificity factor subunit 6; CPSF 68 kDa subunit; Cpsf6; CPSF6_HUMAN; HPBRII 4; HPBRII 7; Pre mRNA
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CPSF6
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
细胞定位：细胞核
剪切及多聚腺苷酸化特异性因子6蛋白抗体产品介绍：background: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008] Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in剪切及多聚腺苷酸化特异性因子6蛋白抗体 association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping. Subcellular Location: Nucleus. In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR.剪切及多聚腺苷酸化特异性因子6蛋白抗体 Similarity: Belongs to the RRM CPSF6/7 family. Contains 1 RRM (RNA recognition motif) domain. Gene ID: 11052 Database links: Entrez Gene: 11052 Human Entrez Gene: 417844 Chicken Entrez Gene: 768231 Cow Entrez Gene: 432508 Mouse Entrez Gene: 299811 Rat Entrez Gene: 446580 Xenopus laevis Omim: 604979 Human SwissProt: Q5ZL34 Chicken SwissProt: Q0P5D2 Cow SwissProt: Q16630 Human SwissProt: Q6NVF9 Mouse SwissProt: Q6DDW4 Xenopus laevis Unigene: 369606 Human Unigene: 478881 Mouse Unigene: 478884 Mouse Unigene: 479892 Mouse Unigene: 7296 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
剪切及多聚腺苷酸化特异性因子6蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid