肌动蛋白结合蛋白1B抗体
规格：1mg/1ml
英文名： CORO1B
别名： COR1B_HUMAN; CORO 1B; CORO1B; Coronin 1B; Coronin 2; Coronin actin binding protein 1B; Coronin-1B; Coronin-2; Coronin1B; Coronin2; DKFZP762I166; OTTHUMP00000236823.
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CORO1B
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞浆
肌动蛋白结合蛋白1B抗体产品介绍：background: Coronins are a family of WD repeat-containing, actin-binding proteins that localize to submembraneous areas and regulate cell motility and cytoskeletal rearrangement. Coronin 1A (CORO1A, CLIPINA, CLABP, TACO, p57) can form coiled coil-mediated homotrimeric complexes that influence early phagosome formation. PKC-dependent phosphorylation of Coronin 1B (CORO1B) at Serine 2 regulates leading edge dynamics and cell motility in fibroblasts through interactions with Arp2/3 complex. Coronin 1C (CORO1C, Coronin 3, HCRNN4) is abundant in differentiating Neuro-2a cells, PC-12 cells and primary oligodendrocytes, where it is thought to influence neuron morphogenesis and migration. Coronin 2A (CORO2A, CLIPINB, IR10, WDR2) is a component of the approximately 1.5-2 megadalton N-CoR (nuclear 肌动蛋白结合蛋白1B抗体receptor corepressor) complex of 10-12 proteins, which recruits HDACs to generate repressive chromatin. Coronin 7 (CORO7, CRN7) localizes to the Golgi membrane and influences the organization of intracellular membrane compartments and vesicular trafficking. Coronin 2B (CORO2B, CLIPINC) and Coronin 6 (CORO6) are similar to other members of this family, since they possess a conserved basic N-terminal motif and 3-10 WD repeats clustered in one to two core domains. Function: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction. Subcellular Location: Cytoplasm > cytoskeleton. Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. Post-translational modifications: Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and 肌动蛋白结合蛋白1B抗体cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location. Similarity: Belongs to the WD repeat coronin family. Contains 5 WD repeats. Gene ID: 57175 Database links: Entrez Gene: 57175 Human Entrez Gene: 510128 Cow Entrez Gene: 23789 Mouse Entrez Gene: 100009415 Rabbit Entrez Gene: 29474 Rat Entrez Gene: 560168 Zebrafish Omim: 609849 Human SwissProt: Q9BR76 Human SwissProt: Q9WUM3 Mouse SwissProt: O89046 Rat Unigene: 6191 Human Unigene: 276859 Mouse Unigene: 2819 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌动蛋白结合蛋白1B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid