CoREST3蛋白抗体
规格：1mg/1ml
英文名： CoREST3
别名： 4921514E24Rik; C730034D20Rik; E130101E15Rik; FLJ10876; FLJ16298; RCOR3_HUMAN; KIAA1343; MGC28186; OTTHUMP00000035053; RCOR3; REST corepressor 3; RP11-318L16.1.
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CoREST3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
CoREST3蛋白抗体产品介绍：background: RCOR2 (REST corepressor 2) and RCOR3 (REST corepressor 3) are nuclear proteins that each contain one ELM2 domain and two SANT domains. RCOR2 and RCOR3, both members of the CoREST family, are thought to function as components of the CoREST complex; possibly playing a role in the transcriptional repression of neuronal genes. Additionally, RCOR2 and RCOR3, in conjunction with CoREST, can form immunocomplexes with a variety of histone-modifying genes, including G9a and HDAC1. Via these protein complexes, RCOR2 and RCOR3 can further regulate transcription by controlling the methylation and demethylation of target genes during early development. While RCOR2 is expressed as only one known isoform, RCOR3 exists as two isoforms due to alternative splicing events. Function: The CoREST3CoREST3蛋白抗体 gene encodes a functional corepressor required for regulation of neural specific gene expression. REST (RE1 silencing transcription factor 1) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long term gene silencing using a distinct functional complex. Silencing of neuronal specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a CoREST3蛋白抗体functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST response elements. Subcellular Location: Nuclear Similarity: Belongs to the CoREST family. Contains 1 ELM2 domain. Contains 2 SANT domains. Gene ID: 55758 Database links: Entrez Gene: 55758 Human Entrez Gene: 214742 Mouse Entrez Gene: 684192 Rat SwissProt: Q9P2K3 Human SwissProt: Q6PGA0 Mouse Unigene: 632489 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CoREST3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid