CoREST2蛋白抗体
规格：1mg/1ml
英文名： CoREST2
别名： 1A13; co repressor of Rest; co-repressor of Rest; coREST; M-CoREST; Rcor; Rcor1; RCOR2; RCOR2_HUMAN; RE1 silencing transcription factor (REST) co repressor 1; RE1-silencing transcription factor (REST)
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CoREST2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Sheep,
细胞定位：细胞核
CoREST2蛋白抗体产品介绍：background: In mammals, the CoREST complex is a chromatin-modifying structure that, through interactions with NRSF (neuron restrictive silencer factor), regulates neuronal gene expression and neuronal cell fate. RCOR2 (REST corepressor 2) and RCOR3 (REST corepressor 3) are nuclear proteins that each contain one ELM2 domain and two SANT domains. RCOR2 and RCOR3, both members of the CoREST family, are thought to function as components of the CoREST complex; possibly playing a role in the transcriptional repression of neuronal genes. Additionally, RCOR2 and RCOR3, in conjunction with CoREST, can form immunocomplexes with a varietyCoREST2蛋白抗体 of histone-modifying genes, including G9a and HDAC1. Via these protein complexes, RCOR2 and RCOR3 can further regulate transcription by controlling the methylation and demethylation of target genes during early development. While RCOR2 is expressed as only one known isoform, RCOR3 exists as two isoforms due to alternative splicing events. Function: May act as a component of a corepressor complex that represses transcription. Subcellular Location: Nucleus. Similarity: Belongs to the CoREST family. Contains 1 ELM2 domain. Contains 2 SANT domains.CoREST2蛋白抗体 Gene ID: 283248 Database links: Entrez Gene: 283248 Human Entrez Gene: 104383 Mouse Entrez Gene: 305811 Rat Entrez Gene: 498485 Rat SwissProt: Q8IZ40 Human SwissProt: Q8C796 Mouse SwissProt: Q5FWT8 Rat Unigene: 98788 Human Unigene: 283859 Mouse Unigene: 110225 Rat Unigene: 209048 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CoREST2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid