扣带蛋白抗体
规格：1mg/1ml
英文名： Cingulin
别名： 6330408J11Rik; AI647528; AI987749; cgn; CING_HUMAN; Cingulin; DKFZp779N1112; FLJ39281; KIAA1319; MGC118157.
分子量： 136kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cingulin
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：
扣带蛋白抗体产品介绍：background: Diffusion of solutes is prevented across certain barriers by the formation of tight junction seals. Occludin and Cingulin interact with other proteins to direct the formation and regulation of tight junctions. Cingulin, a protein component of the submembrane plaque of tight junctions (TJ), contains globular and coiled-coil domains and interacts in vitro with several TJ and cytoskeletal proteins, including the PDZ protein ZO-1. Cingulin binding has also been shown to inhibit RhoA activation and signaling with increased Cingulin expression in扣带蛋白抗体 confluent cells, causing downregulation of RhoA by inhibiting GEF-H1/Lfc. Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Subcellular Location: Cell junction > tight junction. Localizes to the apical扣带蛋白抗体 junction complex composed of tight and adherens junctions. Tissue Specificity: Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart. Similarity: Belongs to the cingulin family. Gene ID: 57530 Database links: Entrez Gene: 57530 Human Omim: 609473 Human SwissProt: Q9P2M7 Human Unigene: 591464 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
扣带蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid