软骨中间层蛋白CILP2抗体
规格：1mg/1ml
英文名： CILP2
别名： Cartilage intermediate layer protein 2 C2; CILP-2; CILP2; CILP2_HUMAN; MGC45771.
分子量： 126kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CILP2
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
软骨中间层蛋白CILP2抗体产品介绍：background: Cartilage intermediate layer protein (CILP), an extracellular matrix protein, shows abundant expression in cartilagenous tissues. CILP is expressed as two isoforms, CILP and CILP-2, which are differentially expressed by chondrocytes and induced by TGF∫1. This induction is mediated by Smad3 through direct interactions with cis-elements in the软骨中间层蛋白CILP2抗体CILP promoter region. TGF∫ also induces elevated chondrocyte extracellular inorganic pyrophosphate (PPi), which promotes the deposition of calcium pyrophosphate dihydrate crystals. The CILP isoforms have been implicated in common musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis and lumbar disc disease. Function: May play a role in cartilage scaffolding. Subcellular Location: Secreted > 软骨中间层蛋白CILP2抗体extracellular space > extracellular matrix. Tissue Specificity: Expressed in articular chondrocytes but not in knee meniscal cartilage cells. Post-translational modifications: May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TSP type-1 domain. Gene ID: 148113 Database links: Entrez Gene: 148113 Human Omim: 612419 Human SwissProt: Q8IUL8 Human Unigene: 279574 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
软骨中间层蛋白CILP2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid