羧酸酯酶3抗体
规格：1mg/1ml
英文名： CES3
别名： Carboxylesterase 3; CES 3; Ces3; ES3; EST3_HUMAN; FLJ21736; Liver carboxylesterase 31 homolog.
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CES3
交叉反应：Human,
细胞定位：
羧酸酯酶3抗体产品介绍：background: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or 羧酸酯酶3抗体full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010] Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. Subcellular Location: Endoplasmic reticulum lumen羧酸酯酶3抗体. Tissue Specificity: Expressed in liver, colon and small intestine. Post-translational modifications: N-glycosylated. Similarity: Belongs to the type-B carboxylesterase/lipase family. Gene ID: 23491 Database links: Entrez Gene: 23491 Human Omim: 605279 Human SwissProt: Q6UWW8 Human Unigene: 268700 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 羧酸酯酶主要位于肝、其他组织及细胞胞液、线粒体和内质网。 是一种多聚蛋白，主要催化酯、硫酸酯和酰胺的水解
羧酸酯酶3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 新陈代谢 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid