CENTA2蛋白抗体
规格：1mg/1ml
英文名： Centaurin alpha 2
别名： ADAP2; ADAP2_HUMAN; Arf-GAP with dual PH domain-containing protein 2; ArfGAP with dual PH domains 2; cent b; Centa 2; CENTA2; Centaurin alpha 2; Centaurin alpha 2 protein; Centaurin beta; Centaurin-al
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Centauri
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
CENTA2蛋白抗体产品介绍：background: The ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of ARF-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1, Centaurin g3 and the recently discovered Centaurin a2. Expressed in a wide variety of tissues such as fat, heart and skeletal muscle, Centaurin a2 is thought to negatively regulate ARF-mediated actin rearrangement by CENTA2蛋白抗体binding activated PI 3-kinase. Although the exact function of Centaurin a2 is not yet known, its high sequence similarity with Centaurin a1 suggests that it may also act as an ARF6 GTPase. Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. Subcellular Location: Cytoplasm. Cell membrane. Constitutively associated with the plasma membrane. Excluded CENTA2蛋白抗体from the nucleus. Tissue Specificity: Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow. Similarity: Contains 1 Arf-GAP domain. Contains 2 PH domains. Gene ID: 55803 Database links: Entrez Gene: 55803 Human Entrez Gene: 216991 Mouse Entrez Gene: 56826 Rat SwissProt: Q9NPF8 Human SwissProt: Q8R2V5 Mouse SwissProt: Q9JK15 Rat Unigene: 514063 Human Unigene: 341520 Mouse Unigene: 203877 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CENTA2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid