CELF3蛋白抗体
规格：1mg/1ml
英文名： CELF3
别名： Bruno-like protein 1; BRUNOL1; CAG repeat protein 4; CAGH4; CELF-3; CELF3; CELF3_HUMAN; CUG-BP- and ETR-3-like factor 3; CUGBP Elav-like family member 3; ELAV-type RNA-binding protein 1; ERDA4; ETR-1;
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CELF3
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow,
细胞定位：细胞核 细胞浆
CELF3蛋白抗体产品介绍：background: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010] Function: RNA-binding CELF3蛋白抗体protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to ***** transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of CELF3蛋白抗体TNNT2 pre-mRNA. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Expressed in brain. Similarity: Belongs to the CELF/BRUNOL family. Contains 3 RRM (RNA recognition motif) domains. Gene ID: 11189 Database links: Entrez Gene: 11189 Human Omim: 612678 Human SwissProt: Q5SZQ8 Human Unigene: 26047 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CELF3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid