肿瘤坏死因子配体超家族成员12抗体
规格：1mg/1ml
英文名： TWEAK
别名： CD 255; CD255; APO 3 ligand; APO 3L; APO3 ligand; APO3/DR3 ligand; APO3L; DR3LG; MGC129581; MGC20669; secreted form; TNF related weak inducer of apoptosis; TNF-related weak inducer of apoptosis; TNF12
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TWEAK/CD
交叉反应：Human,
细胞定位：细胞浆 细胞膜
肿瘤坏死因子配体超家族成员12抗体产品介绍：background: Proteins belonging to the tumor necrosis factor (TNF) superfamily are potent mediators of inflammation and of the immune system. Members of the TNF superfamily include TNFβ, lymphotoxin β (LTb), CD154 (CD40L), CD30L, CD27L, OX40L, 4-1BBL, FAS-L (APO-1) and TRAIL. Most TNF family members are type II transmembrane proteins that are proteolytically processed at their carboxy terminal extracellular domain to form a soluble homotrimeric molecule. TWEAK (also designated Apo-3L) has been identified as a secreted ligand belonging to the TNF superfamily. TWEAK seems to induce apoptosis weakly, and it may be involved in cell 肿瘤坏死因子配体超家族成员12抗体differentiation in vivo. Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Subunit: Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q. Subcellular Location: Secreted and Cell membrane. Tissue Specificity: Highly expressed in ***** heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph肿瘤坏死因子配体超家族成员12抗体 node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. Post-translational modifications: The soluble form derives from the membrane form by proteolytic processing. Similarity: Belongs to the tumor necrosis factor family. Gene ID: 8742 Database links: Entrez Gene: 8742 Human Entrez Gene: 21944 Mouse Entrez Gene: 360548 Rat Omim: 602695 Human SwissProt: O43508 Human SwissProt: O54907 Mouse Unigene: 54673 Human Unigene: 8983 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肿瘤坏死因子配体超家族成员12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid