钙粘蛋白21抗体
规格：1mg/1ml
英文名： PCDH21
别名： Protocadherin 21; Cadherin-related family member 1; CDHR1; CDHR1_HUMAN; CORD15; DKFZp434A132; KIAA1775; MT protocadherin; PCDH 21; PCDH21; PCDH21 protein; Photoreceptor cadherin; prCAD; Protocadherin-
分子量： 91kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PCDH21
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞膜
钙粘蛋白21抗体产品介绍：background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH21 (protocadherin 21), also known as PRCAD, is an 859 amino acid single-pass membrane protein that localizes to the outer segments of photoreceptor cells and contains six cadherin domains. Existing as multiple alternatively spliced isoforms, PCDH21 functions as a calcium-dependent cell adhesion protein that is thought to be required for the structural integrity of photoreceptor cells and may be involved in the formation and maintenance of neuronal networks. Function: Potential calcium-dependent cell-adhesion钙粘蛋白21抗体 protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells. Subcellular Location: Cell membrane. Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip钙粘蛋白21抗体 of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region. Post-translational modifications: Undergoes proteolytic cleavage; produces a soluble 95 kDa N-terminal fragment and a 25 kDa cell-associated C-terminal fragment. Similarity: Contains 6 cadherin domains. Gene ID: 92211 Database links: Entrez Gene: 92211 Human Omim: 609502 Human SwissProt: Q96JP9 Human Unigene: 137556 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙粘蛋白21抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid