PLEKHA7蛋白抗体
规格：1mg/1ml
英文名： PLEKHA7
别名： DKFZp686M22243; PH domain-containing family A member 7; PKHA7_HUMAN; Pleckstrin homology domain containing family A member 2; Pleckstrin homology domain-containing family A member 7; Plekha7.
分子量： 127kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PLEKHA7
交叉反应：Human,
细胞定位：细胞浆 细胞膜
PLEKHA7蛋白抗体产品介绍：background: PLEKHA7 (pleckstrin homology domain containing, family A member 7), also known as PH domain-containing family A member 7, is a 1,121 amino acid protein that contains one PH domain and two WW domains. Encoded by a gene that maps to human chromosome 11p15.1, PLEKHA7 exists as three alternatively spliced isoforms. Localizing to cell-cell junctions in Caco2 cells, PLEKHA7 interacts with the adherens junction protein p120 in human colon carcinoma cells. PLEKHA7 also colocalizes with zona adherens proteins and is necessary for zonula adherens biogenesis and maintenance. Associated with systolic blood pressure (SBP) and hypertension, PLEKHA7 is a potential target for the prevention or treatment of hypertension. PLEKHA7 is also linked to autoimmune hepatitis type 1, a chronic active hepatitisPLEKHA7蛋白抗体 characterized by hypergammaglobulinemia and autoantibodies. Function: Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherensPLEKHA7蛋白抗体, leading to recruit KIFC3 kinesin to junctional site. Subcellular Location: Cell junction > adherens junction. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Localizes to zonula adherens, recruited via its interaction with CTNND1. Similarity: Contains 1 PH domain. Contains 2 WW domains. Database links: Entrez Gene: 144100 Human Omim: 612686 Human SwissProt: Q6IQ23 Human Unigene: 12332 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PLEKHA7蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid