跨膜接头蛋白SIT抗体
规格：1mg/1ml
英文名： SIT
别名： gp30/40; SHP intracting transmembrane adapter protein; SHP2-interacting transmembrane adapter protein; Signaling threshold-regulating transmembrane adapter 1; SIT; Sit1; SIT1_HUMAN; Suppression induci
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SIT
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞膜
跨膜接头蛋白SIT抗体产品介绍：background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and 跨膜接头蛋白SIT抗体cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. Subcellular Location: Cell membrane. Tissue Specificity: Specifically 跨膜接头蛋白SIT抗体expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. Post-translational modifications: Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK. Gene ID: 27240 Database links: Entrez Gene: 27240 Human Entrez Gene: 54390 Mouse Omim: 604964 Human SwissProt: Q9Y3P8 Human SwissProt: Q8C503 Mouse Unigene: 88012 Human Unigene: 31775 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
跨膜接头蛋白SIT抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 **细胞 t-**细胞 b-**细胞 跨膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid