Src激活和信号分子蛋白抗体
规格：1mg/1ml
英文名： TOM1L1
别名： OK/KNS CL.3; Src activating and signaling molecule; Src activating and signaling molecule protein; Src-activating and signaling molecule protein; SRCASM; Target of Myb like protein 1; Target of Myb-li
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TOM1L1
交叉反应：Human, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
Src激活和信号分子蛋白抗体产品介绍：background: Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathwaysSrc激活和信号分子蛋白抗体 and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin. Function: Probable Src激活和信号分子蛋白抗体adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promotes FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. Subunit: Interacts with FYN, GRB2 and PIK3R1 when phosphorylated (By similarity). Interacts with LYN (By similarity). Subcellular Location: Golgi apparatus; Golgi stack. Endosome membrane. Post-translational modifications: Phosphorylated on tyrosines by FYN (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the TOM1 family. Contains 1 GAT domain. Contains 1 VHS domain. Database links: Entrez Gene: 10040 Human Omim: 604701 Human SwissProt: O75674 Human Unigene: 153504 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Src激活和信号分子蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid