磷酸化**细胞胞浆蛋白2抗体
规格：1mg/1ml
英文名： phospho-SLP76 (Tyr145)
别名： SLP76 (phospho Y145); p-SLP76 (Y145); p-LCP2; 76 kDa tyrosine phosphoprotein; CG8697; LCP 2; LCP 2; LCP2; LCP2_HUMAN; Lymphocyte Cytosolic Protein 2; Lymphocyte Cytosolic Protein 2; SH2 Domain Contain
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
磷酸化**细胞胞浆蛋白2抗体产品介绍：background: The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav’s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or磷酸化**细胞胞浆蛋白2抗体 lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation. Function: Involved in T-cell antigen receptor mediated signaling. Subunit: Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB. Interacts with PRAM1. Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, 磷酸化**细胞胞浆蛋白2抗体expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. Post-translational modifications : Phosphorylated after T-cell receptor activation by ZAP-70. Similarity: Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH2 domain. Gene ID: 3937 Database links: Entrez Gene: 3937 Human Omim: 601603 Human SwissProt: Q13094 Human Unigene: 304475 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化**细胞胞浆蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 **细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid