中性鞘磷脂相关因子抗体
规格：1mg/1ml
英文名： NSMAF
别名： Factor associated with N SMase activation; Factor associated with neutral sphingomyelinase; Factor associated with neutral sphingomyelinase activation; FAN; Neutral sphingomyelinase (N SMase) activati
分子量： 104kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NSMAF
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
中性鞘磷脂相关因子抗体产品介绍：background: Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 中性鞘磷脂相关因子抗体activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5). Function: NSMAF is a novel adaptor protein which mediates the activation of sphingomyelinase by receptors such as tumor necrosis factor receptor type 1 and CD40 and subsequent apoptosis in 中性鞘磷脂相关因子抗体cardiomyocytes. Inhibition of this factor may provide a novel intervention point for reducing ischemia/reperfusion injury. Tissue Specificity: Ubiquitous. Similarity: Contains 1 BEACH domain. Contains 1 GRAM domain. Contains 6 WD repeats. Database links: Entrez Gene: 8439 Human Entrez Gene: 18201 Mouse Entrez Gene: 353233 Rat Omim: 603043 Human SwissProt: Q92636 Human SwissProt: O35242 Mouse SwissProt: Q7TSY5 Rat Unigene: 372000 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
中性鞘磷脂相关因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 生长因子和** 细胞膜受体 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid