细胞死亡同源蛋白6抗体
规格：1mg/1ml
英文名： CED6
别名： CED 6; Cell death protein 6 homolog; Engulfment adapter protein; Engulfment adaptor PTB domain containing 1; GULP; GULP, engulfment adaptor PTB domain containing 1; GULP1; GULP1_HUMAN; Protein GULP; P
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CED6
交叉反应：Human, Mouse, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
细胞死亡同源蛋白6抗体产品介绍：background: Several proteins involved in regulating and executing programmed cell death have been identified in C. elegans. CED-3, a member of the ICE protease/caspase family, and CED-4, a homolog of the mammalian Apaf-1, promote apoptosis. CED-9, a homolog of the mammalian Bcl-2 protein, inhibits cell death. EGL-1 and CED-6 both function as death-promoting proteins, with CED-6 playing a role in the engulfment of apoptotic cells. CED-5 and CED-7 are C. elegans orthologs of the mammalian DOCK180 细胞死亡同源蛋白6抗体and ABC transporter proteins, respectively, and also play a role in the engulfment of dying cells. Function: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.细胞死亡同源蛋白6抗体 Subcellular Location: Cytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes. Tissue Specificity: Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary. Similarity: Belongs to the ced-6 family. Contains 1 PID domain. Gene ID: 51454 Database links: Entrez Gene: 51454 Human Entrez Gene: 70676 Mouse Entrez Gene: 314543 Rat Omim: 608165 Human SwissProt: Q9UBP9 Human SwissProt: Q8K2A1 Mouse SwissProt: Q5PQS4 Rat Unigene: 470887 Human Unigene: 712910 Human Unigene: 133132 Mouse Unigene: 32649 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞死亡同源蛋白6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞凋亡 细胞周期蛋白 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid