γ干扰素诱导蛋白IP30抗体
规格：1mg/1ml
英文名： IFI30
别名： Gamma interferon inducible lysosomal thiol reductase; Gamma interferon inducible protein IP 30; GILT; IFI 30; interferon gamma inducible protein 30; Interferon gamma inducible protein 30 preproprotein
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IFI30/GI
交叉反应：Human, Mouse, Rat,
细胞定位：
γ干扰素诱导蛋白IP30抗体产品介绍：background: Proteins internalized into the endocytic pathway are usually degraded. Efficient proteolysis requires denaturation, induced by acidic conditions within lysosomes, and reduction of inter- and intrachain disulfide bonds. Cytosolic reduction is mediated enzymatically by thioredoxin. In the endocytic pathway, reduction of protein disulfide bonds is important for the generation of MHC class II-peptide complexes. This process is catalyzed by a gamma-interferon-inducible thiol reductase (GILT). GILT is synthesized as a precursor, and following delivery to MHC class II-containing compartments (MIICs), is processed to the mature form via cleavage of amino- and γ干扰素诱导蛋白IP30抗体carboxy-terminal propeptides. A lysosomal thiol reductase, GILT, is optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro. GILT is expressed constitutively in antigen-presenting cells and is induced by g-interferon in other cell types, suggesting a potentially important role in antigen processing. Additionally, T cell recognition of select exogenous and endogenous epitopes is dependent on tumor cell expression of GILT. The absence of GILT in melanomas alters antigen processing and the hierarchy of immunodominantγ干扰素诱导蛋白IP30抗体 epitope presentation. Function: The protein encoded by the IFI30 gene is a lysosomal thiol reductase which at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen presenting cells and induced by gamma interferon in other cell types. This enzyme has an important role in MHC class II restricted antigen processing. Subcellular Location: Lysosome. Similarity: Belongs to the GILT family. Gene ID: 10437 Database links: Entrez Gene: 10437 Human Omim: 604664 Human SwissProt: P13284 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
γ干扰素诱导蛋白IP30抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞类型标志物 **细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid