颗粒酶B抗体
规格：1mg/1ml
英文名： Granzyme B
别名： GranzymeB; Granzyme-B; C11; Cathepsin G-like 1; CTLA-1; Cathespin G Like 1; CCPI; CCP-1; CGL 1; CGL1; CSP B; CSPB; CTLA 1;CTLA1; CTSGL 1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T Lymphocyte As
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GZMB
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞浆
颗粒酶B抗体产品介绍：background: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008] Function: This enzyme is necessary for target 颗粒酶B抗体cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. Subcellular Location: Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.颗粒酶B抗体 Similarity: Belongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain. Gene ID: 3002 Database links: Entrez Gene: 3002 Human Entrez Gene: 14939 Mouse Entrez Gene: 171528 Rat Omim: 123910 Human SwissProt: P10144 Human SwissProt: P04187 Mouse SwissProt: P18291 Rat Unigene: 1051 Human Unigene: 14874 Mouse Unigene: 132115 Rat Unigene: 145789 Rat Unigene: 21395 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Granzyme B—是一种丝氨酸蛋白酶,作用在细胞凋亡中。
颗粒酶B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid