粘附调节分子1抗体
规格：1mg/1ml
英文名： ADRM1
别名： 110 kDa cell membrane glycoprotein; adhesion regulating molecule 1; Adhesion-regulating molecule 1; ADRM 1; Adrm1; ADRM1_HUMAN; ARM 1; ARM-1; ARM1; GP110; hRpn13; M(r) 110,000 surface antigen; Proteas
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADRM1
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：细胞核 细胞浆
粘附调节分子1抗体产品介绍：background: ADRM1 is a 407 amino acid protein that localizes to both the nucleus and the cytoplasm and is thought to be involved in protein recruitment and cell adhesion. An integral membrane protein, ADRM1 functions to recruit UCH-L5, a deubiquitinating enzyme, to the 26S proteasome, and once at the proteasome it promotes the activity of UCH-L5. Additionally, ADRM1 is thought to粘附调节分子1抗体 mediate lymphocyte adhesion in endothelial cells and may thus play a role in lymphocyte homing. ADRM1 expression is induced by IFN-g in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis. Two isoforms of ADRM1 exist due to alternative splicing events. Function: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme粘附调节分子1抗体 UCHL5 at the 26S proteasome and promotes its activity. Subunit: Interacts with PSMD1, ubiquitin and UCHL5. Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the ADRM1 family. Contains 1 PH domain. Gene ID: 11047 Database links: Entrez Gene: 11047 Human Entrez Gene: 56436 Mouse Omim: 610650 Human SwissProt: Q16186 Human SwissProt: Q9JKV1 Mouse Unigene: 90107 Human Unigene: 379082 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
粘附调节分子1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞粘附分子 血管内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid