脊髓性肌萎缩症蛋白Gemin7抗体
规格：1mg/1ml
英文名： Gemin 7
别名： SIP3; Gemin7; Gemin-7; GEMI7_HUMAN.
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Gemin 7
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：细胞核
脊髓性肌萎缩症蛋白Gemin7抗体产品介绍：background: Gemin7 is a 131 amino acid protein encoded by the mouse gene Gemin7. Gemin7, along with Gemin6, is a significant component of the the large multiprotein human SMN complex. The SMN complex functions as an assembly machine for small nuclear ribonucleoproteins (snRNPs)-the major components of the spliceosome. The survival of motor neurons (SMN) protein, a product of the disease gene of the common neurodegenerative disease, spinal muscular atrophy, is also part of the SMN complex. Although Gemin6 and Gemin7 have no significant sequence similarity with Sm proteins, both adopt canonical Sm folds. Moreover, Gemin6 and Gemin7 exist as脊髓性肌萎缩症蛋白Gemin7抗体 a heterodimer, and interact with each other via an interface similar to that which mediates interactions among the Sm proteins. The Gemin6/Gemin7 complex binds to Sm proteins and might help organize Sm proteins for formation of Sm rings on snRNA targets. Function: The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. 脊髓性肌萎缩症蛋白Gemin7抗体The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies) and in the cytoplasm. Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN6, SNRPB, SNRPD2, SNRPD3 and SNRPE. Subcellular Location: Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. Similarity: Belongs to the gemin-7 family. Database links: UniProtKB/Swiss-Prot: Q9H840.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脊髓性肌萎缩症蛋白Gemin7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid