γ-微管蛋白GCP6抗体
规格：1mg/1ml
英文名： GCP6
别名： GCP 6; TUBGCP6; tubulin, gamma complex associated protein 6; GCP6_HUMAN.
分子量： 200kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GCP6
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞浆
γ-微管蛋白GCP6抗体产品介绍：background: The g-Tubulin complex is composed of g Tubulin and the g-Tubulin complex-associated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. g-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the g-Tubulin complex. GCP6 (g-Tubulin complex component 6), also known as TUBGCP6, localizes to the centrosome and is a ubiquitously expressed 1,819 amino acid member of the g-Tubulin complex. Unlike GCP3 and GCP2, GCP6 is not well conserved among eukaryotes.γ-微管蛋白GCP6抗体 Three isoforms of GCP6 exist due to alternative splicing events. Function: The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. Subunit: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. DISEASE: Defects in TUBGCP6 are the cause of microcephaly with chorioretinopathy, autosomal recessive (MCPHCR) [MIM:251270]. A syndrome characterized by microcephaly, γ-微管蛋白GCP6抗体cognitive impairment, underdeveloped retina and choroid, and epilepsy in some patients. The more anterior parts of the retina, near the periphery and pars plana, have a grayish hue and diminutive vasculature similar to retinopathy of prematurity. Visual impairment becomes evident during the first year of life. Similarity: Belongs to the TUBGCP family. Gene ID: 85378 Database links: Entrez Gene: 85378 Human Omim: 610053 Human SwissProt: Q96RT7 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
γ-微管蛋白GCP6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid