GTP环反馈调节蛋白抗体
规格：1mg/1ml
英文名： GCHFR
别名： GCHFR; GFRP; GFRP_HUMAN; GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulator; GTP cyclohydrolase I feedback regulatory protein; HsT16933; MGC138467; MGC138469; p3
分子量： 10kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GCHFR
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow,
细胞定位：细胞核 细胞浆 细胞膜
GTP环反馈调节蛋白抗体产品介绍：background: GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. The molecular weight of GFRP is approximately 9.5kDa although cross-linking experiments have shown that GFRP is usually found as a homodimer or as a pentamer. 15q15. Function: Mediates GTP环反馈调节蛋白抗体tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Subunit: Homopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers (By similarity). Interacts with GCH1. Subcellular Location: Nucleus. Nucleus membrane. Cytoplasm; cytosol. Tissue Specificity: In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). Similarity: Belongs to the GFRP family. Gene ID: 2644 Database links: EntrezGTP环反馈调节蛋白抗体 Gene: 2644 Human Entrez Gene: 320415 Mouse Entrez Gene: 171128 Rat Omim: 602437 Human SwissProt: Q32L41 Cow SwissProt: P30047 Human SwissProt: P99025 Mouse SwissProt: P70552 Rat Unigene: 631717 Human Unigene: 86373 Mouse Unigene: 11137 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GTP环反馈调节蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 新陈代谢 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid