晶状体球蛋白γ3/γC-crystallin/白内障相关蛋白抗体
规格：1mg/1ml
英文名： gamma C Crystallin
别名： CATARACT, VARIABLE ZONULAR PULVERULENT; CCL; CRGC_HUMAN; CRYG 3; Cryg 5; Cryg; CRYG3; CRYGC; Crystallin gamma 3; Crystallin gamma C; Gamma C crystallin; Gamma crystallin 2 1; Gamma crystallin 3; Gamma
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human gamma C
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：
晶状体球蛋白γ3/γC-crystallin/白内障相关蛋白抗体产品介绍：background: Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into alpha, beta, and gamma families, and the beta and gamma-crystallins also comprise a superfamily. Crystallins usually contain seven distinctive protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. gamma-crystallins are structural proteins in the lens, and they exists as monomers which typically lack connecting peptides and terminal extensions. The gamma-crystallins include seven closely related gamma A, gamma B, gamma C, gamma D, gamma E, gamma F, and gamma G-crystallin, as well as the gamma N and gamma S-crystallin genes. The gamma-crystallins are 晶状体球蛋白γ3/γC-crystallin/白内障相关蛋白抗体differentially regulated after early development, and are involved in cataract formation as a result of either age-related protein degradation or genetic mutation. Function: Crystallins are the dominant structural components of the vertebrate eye lens. Subunit: Monomer (By similarity). DISEASE: Defects in CRYGC are a cause of cataract autosomal dominant (ADC) [MIM:604219]. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a晶状体球蛋白γ3/γC-crystallin/白内障相关蛋白抗体 portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood. Defects in CRYGC are a cause of cataract Coppock-like (CCL) [MIM:604307]. A congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited. Similarity: Belongs to the beta/gamma-crystallin family. Contains 4 beta/gamma crystallin 'Greek key' domains. Database links: Entrez Gene: 1420 Human Omim: 123680 Human SwissProt: P07315 Human Unigene: 72910 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
晶状体球蛋白γ3/γC-crystallin/白内障相关蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid