GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体
规格：1mg/1ml
英文名： GABPB2
别名： MGC29891; BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GA binding protein transcription factor beta subunit 1 transcript variant gamma 2; GA binding protein transcription factor, beta subunit 1; GA bind
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GABPB2/G
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse,
细胞定位：细胞核
GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体产品介绍：background: The transcription factor GA-binding protein (GABP) is composed of two subunits, the Ets-related GABP-alpha and a GABP-alpha-associated subunit, GABP beta. GABP alpha binds to a specific DNA sequence and GABP beta exists as b1 and b2 splice variants that differ in their C-termini. In primary neuronal cultures, GABP beta is expressed in both the cytoplasm and the nucleus, whereas GABP alpha is expressed mainly in the nucleus. GABP is constitutively expressed as either a GABP alpha beta heterodimer or a GABP alpha b heterotetramer, both of which can modify GABP-dependent transcription in vitro and in vivo . GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体The GABP alpha beta tetrameric complex performs many different functions, such as stimulating transcription of the adenovirus E4 gene, differentially activating BRCA1 expression in human breast cell lines, potentiating Tat-mediated activation of long terminal repeat promoter transcription and viral replication in certain cell types, acting as a coordinator of mitochrondrial and nuclear transcription for cytochrome oxidase in neurons and assisting in the regulation of rpL32 gene transcription. Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. Subunit: Heterotetramer of two alpha and two beta subunitsGA结合蛋白转录因子β/GABP-β1/GABP-β2抗体. Interacts with HCFC1, causing repression of transcriptional activity. Subcellular Location: Nucleus. Similarity: Contains 5 ANK repeats. Database links: Entrez Gene: 2553 Human Entrez Gene: 14391 Mouse Entrez Gene: 364738 Rat Omim: 600610 Human SwissProt: Q06547 Human SwissProt: Q00420 Mouse Unigene: 654350 Human Unigene: 293266 Mouse Unigene: 61149 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid