G氨基丁酸受体pi/GABAA Rπ抗体
规格：1mg/1ml
英文名： GABA A receptor pi
别名： GABA(A) receptor; GABA(A) receptor subunit pi; GABRP; Gamma aminobutyric acid (GABA) A receptor pi; Gamma aminobutyric acid A receptor pi; Gamma aminobutyric acid receptor pi subunit; Gamma aminobutyr
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GABRP/GA
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
G氨基丁酸受体pi/GABAA Rπ抗体产品介绍：background: GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (Gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. G氨基丁酸受体pi/GABAA Rπ抗体The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Subcellular Location: Cell junction; synapse; postsynaptic cell membrane. Cell membrane. Tissue Specificity: Most abundant in the uterus, also expressed in lung, thymus and prostate. Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9)G氨基丁酸受体pi/GABAA Rπ抗体 family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily. Database links: Entrez Gene: 2568 Human Entrez Gene: 216643 Mouse Entrez Gene: 81658 Rat Entrez Gene: 517459 Cow Entrez Gene: 489124 Dog Omim: 602729 Human SwissProt: Q5EA06 Cow SwissProt: O00591 Human SwissProt: Q8QZW7 Mouse SwissProt: O09028 Rat Unigene: 26225 Human Unigene: 99989 Mouse Unigene: 21401 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G氨基丁酸受体pi/GABAA Rπ抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid