生长因子受体结合蛋白2相关蛋白3抗体
规格：1mg/1ml
英文名： GAB3
别名： Gab3; GAB3_HUMAN; GRB2-associated binder 3; GRB2-associated-binding protein 3; Growth factor receptor bound protein 2-associated protein 3.
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GAB3
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：
生长因子受体结合蛋白2相关蛋白3抗体产品介绍：background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (1–3). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (1–3). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 生长因子受体结合蛋白2相关蛋白3抗体domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5). Subunit生长因子受体结合蛋白2相关蛋白3抗体: Interacts with PIK3R/p85, SHP2 and GRAP2/MONA (By similarity). May interact with Grb2. Post-translational modifications: Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation. Similarity: Belongs to the GAB family. Contains 1 PH domain. Database links: UniProtKB/Swiss-Prot: Q8WWW8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长因子受体结合蛋白2相关蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 生长因子和** 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid