X三体综合症相关蛋白FUNDC1抗体
规格：1mg/1ml
英文名： FUNDC1
别名： FUN14 domain containing protein 1; FUN14 domain-containing protein 1; FUND1_HUMAN.
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FUNDC1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：
X三体综合症相关蛋白FUNDC1抗体产品介绍：background: FUNDC1 is a 155 amino acid protein belonging to the FUN14 family. The gene encoding FUNDC1 maps to human chromosome Xp11.3 and mouse chromosome X A1.2. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the XX三体综合症相关蛋白FUNDC1抗体 chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Subunit: Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP. Subcellular Location: Mitochondrion outer membrane;X三体综合症相关蛋白FUNDC1抗体 Multi-pass membrane protein. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy. Similarity: Belongs to the FUN14 family. Database links: UniProtKB/Swiss-Prot: Q8IVP5.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
X三体综合症相关蛋白FUNDC1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 发育生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid