岩藻糖变旋酶/Fucose mutarotase抗体
规格：1mg/1ml
英文名： Fukutin
别名： C10orf125; Chromosome 10 open reading frame 125; FUCM_HUMAN; Fucose mutarotase; FUCU; Protein fucU homolog.
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Fukutin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：
岩藻糖变旋酶/Fucose mutarotase抗体产品介绍：background: Fukutin, a secreted protein, is expressed in various tissues in normal individuals. Fukutin colocalizes with a Golgi marker and a granular cytoplasmic distribution, suggesting that fukutin passes through the Golgi before being packaged into secretory vesicles. Fukutin may be located in the extracellular matrix, where it interacts with and reinforces a large complex encompassing the outside and inside of muscle membranes; alternatively, as a secreted protein, fukutin may cause muscular dystrophy by an unknown mechanism. The fukutin gene is expressed at similar levels in control fetal and ***** brain, but is much reduced in Fukuyama congenital muscular dystrophy (FCMD) brains. Fukutin deficiency affects the modification of glycosylation of DAG1 (α-dystroglycan), which then cannot localize or function properly and may be degraded or eluted from the extracellular surface membrane of the muscle fiber. FCMD is the first human disease known 岩藻糖变旋酶/Fucose mutarotase抗体to be caused by an ancient retrotransposal integration. The gene which encodes fukutin maps to human chromosome 9q31. Function: Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases岩藻糖变旋酶/Fucose mutarotase抗体. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. Subunit: Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive (By similarity). Similarity: Belongs to the rbsD / fucU family. Database links: Entrez Gene: 282969 Human SwissProt: A2VDF0 Human Unigene: 155823 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
岩藻糖变旋酶/Fucose mutarotase抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid