DNA解旋酶V抗体
规格：1mg/1ml
英文名： FUBP1
别名： FBP1; DNA helicase V; far upstream element (FUSE) binding protein 1; Far upstream element (FUSE) binding protein 4; Far upstream element binding protein 1; far upstream element binding protein; Far up
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FUBP1/DN
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
细胞定位：细胞核
DNA解旋酶V抗体产品介绍：background: Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation DNA解旋酶V抗体domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation. Function: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. Subunit: Found in a complex with PUF60 and far upstream element (FUSE) DNA segment. Interacts with PUF60 and JTV1. Subcellular Location: Nucleus. Post-translational modifications: Ubiquitinated. This targets the protein for proteasome-mediated degradation. DNA解旋酶V抗体Similarity: Contains 4 KH domains. Database links: Entrez Gene: 8880 Human Entrez Gene: 51886 Mouse Entrez Gene: 654496 Rat Entrez Gene: 513562 Cow Omim: 603444 Human SwissProt: Q96AE4 Human SwissProt: Q91WJ8 Mouse SwissProt: Q32PX7 Rat Unigene: 567380 Human Unigene: 278922 Mouse Unigene: 177078 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DNA解旋酶V抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid