**管内皮透明质酸受体抗体
规格：1mg/1ml
英文名： LYVE-1
别名： LYVE1; lymphalic vessel endotheilial hyaluronan receptor 1; CRSBP 1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; HAR; hyaluronic acid receptor; Cell surface
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse LYVE-1 t
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜 细胞外基质
**管内皮透明质酸受体抗体产品介绍：background: The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on**管内皮透明质酸受体抗体 the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. Function: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for **管内皮透明质酸受体抗体catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Subunit: Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN. Subcellular Location: Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Post-translational modifications: O-glycosylated. Similarity: Contains 1 Link domain. Gene ID: 114332 Database links: Entrez Gene: 10894 Human Entrez Gene: 114332 Mouse Omim: 605702 Human SwissProt: Q9Y5Y7 Human SwissProt: Q8BHC0 Mouse Unigee: 246769 Human Unigene: 655332 Human Unigene: 396078 Mouse Important Note: This product as supplied is intended for research use only, not for use in **管内皮透明质酸受体抗体human, therapeutic or diagnostic applications. **管标志物 LYVE-1是一种特异性氨基葡聚糖透明质酸受体，均匀分布在**管的管腔面和基底膜，目前多用于肿瘤**转移方面的研究。 **管内皮细胞透明质酸受体1（LYVE1)LYVE1是位于**管内皮细胞上的含有322个氨基酸残基的膜蛋白。与CD44糖蛋白同源，均匀分布于**管内外腔面，可与细胞外基质的葡萄糖胺聚糖透明质酸结合，具有从组织摄取透明质酸盐并转运至**液的作用。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid