DNA聚合酶θ/DNA pol θ抗体
规格：1mg/1ml
英文名： DNA Polymerase theta/POLH
别名： DKFZp781A0112; DNA polymerase eta; DNA polymerase theta; DPOLQ_HUMAN; POLH; POLQ; Polymerase (DNA directed) theta; PRO0327.
分子量： 290kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DNA Poly
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
细胞定位：
DNA聚合酶θ/DNA pol θ抗体产品介绍：background: DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol alpha, beta, gamma, and e are involved in DNA replication and repair (4). DNA pol gammaand DNA pol e are multisubunit enzymes, with DNA pol 佪 consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5).DNA聚合酶θ/DNA pol θ抗体 The nuclear-encoded DNA pol delta is the only DNA polymerase required for the replication of the mitochondrial DNA (6). Function: Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links. Tissue Specificity: Highly expressed in testis. Similarity: Belongs to the DNA polymerase type-A family. Contains 1 helicase ATP-binding domain.DNA聚合酶θ/DNA pol θ抗体 Contains 1 helicase C-terminal domain. Database links: Entrez Gene: 10721 Human Entrez Gene: 77782 Mouse Omim: 604419 Human SwissProt: O75417 Human Unigene: 241517 Human Unigene: 259114 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DNA聚合酶θ/DNA pol θ抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 亱C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid