磺基转移酶CSPS抗体
规格：1mg/1ml
英文名： CSPS/MPST
别名： Aryl sulfotransferase 1A3/1A4; Aryl sulfotransferase; Catecholamine Sulfating Phenol Sulfotransferase; Catecholamine-sulfating phenol sulfotransferase; Dopamine specific sulfotransferase; FLJ54864; HA
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CSPS
交叉反应：Human, Mouse, Rat, Cow, Rabbit, Sheep,
细胞定位：细胞浆
磺基转移酶CSPS抗体产品介绍：background: Cysteine string proteins (CSPs) are synaptic vesicle-associated, secretory vesicle proteins that are involved in Ca2+-regulated exocytosis of synaptic vesicles and modulation of presynaptic transmembrane calcium fluxes in neuroendocrine and endocrine cell types. CSP contains a J-domain that binds HSP 70/HSC 70 chaperone ATPases and a membrane-targeting, palmitoylated cysteine-rich string region. CSPs may act as molecular chaperones in synapses, and mediate conformational folding of components of the vesicular exocytotic machinery. CSP is involved in the fine tuning of neurotransmission through its interaction with receptor-coupled trimeric GTP binding proteins 磺基转移酶CSPS抗体(G proteins) and N-type Ca2+ channels. Two variants of CSP have been described: CSP1; and the 31 amino acid, C-terminally truncated isoform, CSP2. Subcellular fractionation of insulinoma cells shows CSP1 in granular fractions, while the membrane and cytosol fractions contain predominantly CSP2. The fractions also contain additional proteins, presumably CSP dimers. Furthermore, in various mammalian cell lines (including rat brain) CSP1 expression predominates CSP2 expression. Function: Catalyzes the sulfate conjugation of phenolic monoamines (neurotransmitters such 磺基转移酶CSPS抗体as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. Subunit: Homodimer. Subcellular Location: Cytoplasm. Tissue Specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte. Post-translational modifications: The N-terminus is blocked. Similarity: Belongs to the sulfotransferase 1 family. Database links: Entrez Gene: 445329 Human Entrez Gene: 6818 Human Omim: 600641 Human SwissProt: P50224 Human Unigene: 460558 Human Unigene: 728806 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磺基转移酶CSPS抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid