半胱氨酸延伸蛋白α抗体
规格：1mg/1ml
英文名： CSP
别名： CLN 4; CLN4; CLN4B; CSP; cysteine string protein alpha; Cysteine string protein; DJC5; DnaJ (Hsp40) homolog subfamily C member 5; DnaJ homolog subfamily C member 5; DNAJC 5; Dnajc5; DNAJC5A; DNJC5_HUM
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CSP
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
细胞定位：细胞膜
半胱氨酸延伸蛋白α抗体产品介绍：background: Cysteine string proteins (CSPs) are synaptic vesicle-associated, secretory vesicle proteins that are involved in Ca2+-regulated exocytosis of synaptic vesicles and modulation of presynaptic transmembrane calcium fluxes in neuroendocrine and endocrine cell types. CSP contains a J-domain that binds HSP 70/HSC 70 chaperone ATPases and a membrane-targeting, palmitoylated cysteine-rich string region. CSPs may act as molecular chaperones in synapses, and mediate conformational folding of components of the vesicular exocytotic machinery. CSP is involved in the fine tuning of neurotransmission through its interaction with receptor-coupled trimeric GTP binding proteins (G proteins) and N-type Ca2+ channels. Two variants of CSP have been described: CSP1; and the 31 amino acid, C-terminally truncated i半胱氨酸延伸蛋白α抗体soform, CSP2. Subcellular fractionation of insulinoma cells shows CSP1 in granular fractions, while the membrane and cytosol fractions contain predominantly CSP2. The fractions also contain additional proteins, presumably CSP dimers. Furthermore, in various mammalian cell lines (including rat brain) CSP1 expression predominates CSP2 expression. Function: May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Subunit: Homodimer (Probable). Interacts with the chaperone complex consisting of HSC70 and SGTA (By similarity). Subcellular Location: Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Tissue Specificity: Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. Post-translational modifications:半胱氨酸延伸蛋白α抗体 Fatty acylated. Heavily palmitoylated in the cysteine string motif. DISEASE: Neuronal ceroid lipofuscinosis 4B (CLN4B) [MIM:162350]: An *****-onset neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. CLN4B has no visual involvement and is characterized by seizures and other neurologic symptoms. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 J domain. Database links: Entrez Gene: 80331 Human Entrez Gene: 13002 Mouse Entrez Gene: 79130 Rat Omim: 611203 Human SwissProt: Q9H3Z4 Human SwissProt: P60904 Mouse SwissProt: P60905 Rat Unigene: 164419 Human Unigene: 140761 Mouse Unigene: 391807 Mouse Unigene: 100120 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
半胱氨酸延伸蛋白α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid