富半胱氨酸肝素结合蛋白61抗体
规格：1mg/1ml
英文名： CCN1
别名： Cyr61; IGFBP10; cysteine rich protein 61; 3CH61; CCN 1; CCN1; CYR 61; CYR61; CYR61 protein; CYR61 protein precursor; Cysteine rich angiogenic inducer 61; Cysteine rich heparin binding protein 61; GIG
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cyr61
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：分泌型蛋白
富半胱氨酸肝素结合蛋白61抗体产品介绍：background: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C富半胱氨酸肝素结合蛋白61抗体, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Subcellular Location: Secreted. Similarity: Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 富半胱氨酸肝素结合蛋白61抗体1 TSP type-1 domain. Contains 1 VWFC domain. Gene ID: 3491 Database links: Entrez Gene: 3491 Human Entrez Gene: 16007 Mouse Entrez Gene: 83476 Rat Entrez Gene: 508941 Cow Omim: 602369 Human SwissProt: O00622 Human SwissProt: P18406 Mouse SwissProt: Q9ES72 Rat Unigene: 8867 Human Unigene: 1231 Mouse Unigene: 22129 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 高半胱氨酸蛋白61是富含半胱氨酸的分泌性肝素连接蛋白，是CCN家族成员之一，属于生长因子诱导的即刻早期基因，有明显的促有丝分裂和趋化活性作用，有诱导成纤维细胞增殖和分泌细胞外基质等功能，可促进细胞增殖、迁移、黏附、分化和细胞外基质（ECM）合成的作用，在新生血管及肿瘤形成过程中起着重要作用。
富半胱氨酸肝素结合蛋白61抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid