调节中心体分离早期相关激酶BORA抗体
规格：1mg/1ml
英文名： BORA
别名： Aurora borealis; bora; BORA_HUMAN; C13orf34; Chromosome 13 open reading frame 34; FLJ22624; HsBora; Protein aurora borealis; RP11-342J4.2.
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BORA
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
调节中心体分离早期相关激酶BORA抗体产品介绍：background: Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to调节中心体分离早期相关激酶BORA抗体 the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding 调节中心体分离早期相关激酶BORA抗体Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked. Function: Required for the activation of Aurora-A (AURKA/STK6) at the onset of mitosis. Subunit: Interacts with AURKA. Post-translational modifications: Phosphorylated by AURKA/STK6. Similarity: Belongs to the BORA family. Database links: UniProtKB/Swiss-Prot: Q6PGQ7.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
调节中心体分离早期相关激酶BORA抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid