前列腺跨膜上皮3抗原抗体
规格：1mg/1ml
英文名： STEAP3
别名： 1010001D01Rik; Dudlin 2; Dudlin2; Dudulin 2; Dudulin-2; Dudulin2; hpHyde; hTSAP6; Metalloreductase STEAP3; MGC93147; pHyde; Six transmembrane epithelial antigen of prostate 3; Six transmembrane prosta
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human STEAP3
交叉反应：Human, Mouse, Rat,
细胞定位：
前列腺跨膜上皮3抗原抗体产品介绍：Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. Subcellular Location: Endosome 前列腺跨膜上皮3抗原抗体membrane. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Tissue Specificity: Expressed in ***** bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. Post-translational modifications: Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent前列腺跨膜上皮3抗原抗体 manner. Glycosylated. DISEASE: Anemia, hypochromic microcytic, with iron overload 2. Similarity: Belongs to the STEAP family. Contains 1 ferric oxidoreductase domain. Database links: Entrez Gene: 55240 Human Entrez Gene: 68428 Mouse Entrez Gene: 170824 Rat Omim: 609671 Human SwissProt: Q658P3 Human SwissProt: Q8CI59 Mouse SwissProt: Q5RKL5 Rat Unigene: 647822 Human Unigene: 181033 Mouse Unigene: 16304 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
前列腺跨膜上皮3抗原抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid