液泡蛋白分选蛋白33B抗体
规格：1mg/1ml
英文名： VPS33B
别名： FLJ14848; hVPS 33B; hVPS33B; Vacuolar protein sorting 33 homolog B (yeast); Vacuolar protein sorting 33 homolog B; Vacuolar protein sorting 33B (yeast); Vacuolar protein sorting 33B; Vacuolar protein
分子量： 71kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VPS33B
交叉反应：Human, Mouse, Rat, Chicken,
细胞定位：细胞浆
液泡蛋白分选蛋白33B抗体产品介绍：background: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by 液泡蛋白分选蛋白33B抗体RefSeq, Jan 2014] Function: May play a role in vesicular trafficking during spermatogenesis (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of E-cadherin Subunit: Associates with the homotypic fusion and vacuole protein sorting (HOPS) complex. Interacts with VPS33A and VPS33B. Interacts with RAB11A. Subcellular Location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes. Colocalizes in clusters with 液泡蛋白分选蛋白33B抗体VIPAS39 at cytoplasmic organelles. Similarity: Belongs to the SPE39 family. Database links: Entrez Gene: 25858 Chicken Entrez Gene: 526538 Cow Entrez Gene: 26276 Human Entrez Gene: 233405 Mouse Entrez Gene: 64060 Rat Omim: 608552 Human SwissProt: Q2HJ18 Cow SwissProt: Q9H267 Human SwissProt: P59016 Mouse SwissProt: Q63616 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. The disease is caused by mutations affecting the gene represented in this entry. In liver, CEACAM5 and ABCB11 are mislocalized and E-cadherin expression is decreased. Disease description:A multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is common.
液泡蛋白分选蛋白33B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid